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2mg xanax and 10mg ambien for 4 weeks (total daily dosage 150mg xanax and 100mg ambien), after which patients were switched to placebo. Results showed the number of sleeping problems was not changed, but anxiety and insomnia symptoms were reduced. Patients rated their overall satisfaction with the trial as 8 out of 10. These improvements were related to improvement in a wide variety of mental states, which were assessed using the SCL-90-R and the MADRS. Both the SCL-90-R and the MADRS showed improvements in major depression, the most common psychiatric disorder in the world. However, ambien had a smaller benefit at the end of the trial (p value < 0.05), whereas the effects of xanax were similar, being significant at the end of the trial. This study suggests that the anxiolytic effects of xanax are dependent on the dosage, rather than anxiolytic effect being related to anxiolytic dose. These findings suggest that xanax (200mg-400mg daily for 4 weeks) is more effective than Ambien at reducing the incidence of insomnia and improving daily functioning of patients with insomnia. The results also showed that a low dosage of ambien was more effective than a high dosage of xanax to treat insomnia symptoms. Ambien is considered to be the first new long-acting antipsychotic agent. A high dose of xanax is still prescribed, however, with a limited effect: the clinical effect of xanax is a reduction in daytime sleepiness and a reduction in daytime wakefulness with a dose of 200mg in humans. This study shows the anxiolytic effects of a low dosage of the benzodiazepine are dependent on the dosage rather than the anxiolytic effect being related to the benzodiazepine dose. This may help predict the anxiolytic side effects of various benzodiazepines and thus help physicians select the best benzodiazepine that has no sedative effects. The new anxiolytic xanax (200 mg for 4 weeks) has a stronger anxiolytic effect than the old long-acting anxiolytic zolpidem (20 or 40 mg daily). This may help predict the clinical anxiolytic side effects of other benzodiazepines but will not help predict the anxiolytic side effects of the new medication for treating insomnia. Another study of the effect of the new anxiolytic xanax 200 mg/day on insomnia and anxiety was conducted by Bhatiya et al. (2011). Sleep-Wake Induced Symptoms, Clinical Severity Scale, and Total Sleep Time in Healthy Adults with Chronic Insomnia: A Randomized, Double-blind, Placebo-Controlled Study. DOI: 10.1371/journal.pone.0084737. The authors’ goal was to examine the anxiolytic effect of xanax in subjects without cardiovascular issues, using the SCL-90-R and the MADRS to evaluate the clinical status as well as their sleep pattern. The sample included 18 subjects with chronic insomnia who were randomized to receive either a single 200 mg dose of xanax, or a placebo. Compared to patients given placebo, those receiving xanax did not show significant improvement on the sleep parameters and sleep onset latency, but demonstrated significant improvement in depression and anxiety. When participants with insomnia were evaluated using the SCL-90-R, they showed a significant difference in depressive scores from baseline. The study also utilized an 8-point measure that measures total sleep time and the SCL-90-R as well as the SCL-90-R total score, to evaluate the efficacy of the medication. Patients receiving xanax demonstrated significantly more sleep and sleep quality than did participants receiving placebo. No significant